Table 1.
Ingenuity Pathway Analysis of endometrial genes differentially expressed at week 5
| Pathway or Biological Function | Z-score | P-value |
|---|---|---|
| Cyclic vs non-cyclic (n = 809 DEG) | ||
| Canonical Pathway - Decreased | ||
| EIF2 signaling (i.e., protein synthesis) | 6.16E-10 | |
| Biological Functions - Increased | ||
| Transport of molecule | 2.809 | 5.01E-05 |
| Transport of lipid | 2.753 | 7.24E-03 |
| Oxidation of lipid | 2.325 | 5.03E-03 |
| Quantity of carbohydrate | 2.057 | 1.72E-04 |
| Cell-cell contact | 2.295 | 5.25E-03 |
| Fusion of cells | 2.266 | 2.02E-03 |
| Formation of muscle | 2.209 | 3.63E-03 |
| Head and neck cancer | 2.4 | 6.69E-03 |
| Biological Functions - Decreased | ||
| Cell death | −2.193 | 2.11E-03 |
| Necrosis | − 2.493 | 2.45E-03 |
| Astrocytosis | −2.353 | 3.53E-03 |
| Liver lesion | −2.452 | 1.71E-04 |
| Week 1 microbiota (WK1_PC1; n = 516 DEG) | ||
| Biological functions - Increased | ||
| Thoracic hypoplasia | 2.44 | 1.73E-05 |
| Cardiac lesion | 2.423 | 8.65E-03 |
| Fibrosis of heart | 2.241 | 6.66E-03 |
| Biological functions - Decreased | ||
| Organization of cytoplasm | −2.383 | 1.32E-03 |
| Organization of cytoskeleton | −2.383 | 1.41E-03 |
| Proliferation of neuroblastoma cell lines | −2.412 | 6.95E-03 |
| Formation of muscle cells | −2.607 | 4.07E-04 |
| Formation of muscle | −2.902 | 2.44E-04 |
| Week 5 microbiota (WK5_PC1; n = 96 DEG) | ||
| Biological functions - Decreased | ||
| Organismal death | −2.35 | 3.58E-03 |
| Thoracic hypoplasia | −2 | 7.07E-03 |