Table 3.
Cox Regression of morphometric vitronectin variables and INRG prognostic factors
| Variable | B | S.E | Wald | Exp (B) (95% CI) | p-value |
|---|---|---|---|---|---|
| EFS | |||||
| Age (≥18 month) | 1.361 | 0.526 | 6.696 | 3.898 (1.39–10.92) | 0.010 |
| Hist.D (uNB/pdNB) | 1.073 | 0.411 | 6.806 | 2.924 (1.30–6.54) | 0.009 |
| 11q status (11qD) | 0.883 | 0.424 | 4.332 | 2.418 (1.05–5.55) | 0.037 |
| OS | |||||
| Age (≥18 month) | 1.320 | 0.603 | 4.797 | 3.745 (1.14–12.20) | 0.029 |
| 11q status (11qD) | 1.309 | 0.469 | 7.785 | 3.702 (1.47–9.28) | 0.005 |
| *MYCN (MNA) | 0.857 | 0.472 | 3.296 | 2.357 (0.94–5.94) | 0.069 |
| *Terr. VN_Q3 | 0.852 | 0.480 | 3.154 | 2.344 (0.92–6) | 0.076 |
Significant INRG prognostic parameters and morphometric vitronectin (VN) measurements predictive of poor outcome in neuroblastoma (NB) patients based on event-free survival (EFS) and overall survival (OS) with p-value < 0.05 and *p-value < 0.1. Hist.D: histopathologic differentiation; uNB: undifferentiated neuroblastoma; pdNB: poorly differentiated neuroblastoma; 11qD: 11q deletion; MNA: MYCN amplified; Terr.VN_Q3: Territorial vitronectin dichotomized at the third quartile. B: Beta coefficient; S.E: Standard Error; CI: Confidence interval. Coefficients Exp (B) > 1 indicate that high values of this parameter increase the probability of it being an independent poor prognostic factor