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. 2019 May 22;16:109. doi: 10.1186/s12974-019-1501-9

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Heat map of genes differentially expressed between TMEV-IDD and R-EAE mice and their respective age-matched controls. Blue indicates an expression below the mean value, black near the mean value, and yellow above the mean value. Four different sub-clusters were identified. Sub-cluster #1 contains genes that do not change in TMEV-IDD but are downregulated in R-EAE. In sub-cluster #2, genes are upregulated in TMEV-IDD only. Sub-cluster #3 includes genes upregulated in both TMEV-IDD and R-EAE. In sub-cluster #4, genes are upregulated in R-EAE only