Fig. 6.
Blood-brain barrier function in R-EAE and TMEV-IDD. Albumin CSF/serum ratio evaluation (QAlb) showed significantly increased values in R-EAE, which may reflect blood-brain barrier (BBB) breakdown in R-EAE mice. The integrity of the BBB permeability in TMEV-IDD is confirmed by the Qalbumin values similar to sham mice. Data are representative of 2 independent experiments (n = 26) for TMEV-IDD and 2 experiments (n = 22) for R-EAE. Since age may affect albumin expression and overall BBB permeability, 10-week-old sham SJL/J mice (sham#1, n = 4) and 24-week-old sham-treated SJL/J mice (sham#2, n = 12) were used as controls for R-EAE and TMEV-IDD, respectively. Values are expressed as mean ± SEM. *For comparisons between the disease model (either R-EAE or TMEV-IDD) and its age-matched sham control group. ^For comparisons between R-EAE and TMEV-IDD. *^p < 0.05