Fig. 7.
Intrathecal synthesis of immunoglobulins in R-EAE and TMEV-IDD. Indices (QIg/Qalbumin) of all tested Igs (a–d), except for IgG3 and IgM (e, f), were significantly increased in TMEV-IDD mice compared to both R-EAE mice and age-matched sham controls (sham#2), reflecting significant intrathecal production of Igs. Data are representative of 2 independent experiments (n = 26) for TMEV-IDD and 2 experiments (n = 13) for R-EAE. Since the age of SJL/J mice could account for Ig levels, 10-week-old sham SJL/J mice (sham#1, n = 4) and 24-week-old sham-treated SJL/J mice (sham#2, n = 12) were used as controls for R-EAE and TMEV-IDD, respectively. Values are expressed as mean ± SEM. In f, an outlier is shown. *For comparisons between the disease model (either R-EAE or TMEV-IDD) and its age-matched sham control group. ^For comparisons between R-EAE and TMEV-IDD. #For comparisons between the two sham control groups. ****p < 0.0001; ***p < 0.001; **p < 0.01; *p < 0.05