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. 2019 May 22;20:102. doi: 10.1186/s13059-019-1706-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — ChiCMaxima precisely calls chromatin interactions. a mES CHi-C (upper panel) and 4C (lower panel) profiles centered on the bait Dek promoter are shown. The interactions called by ChiCMaxima and CHiCAGO are denoted as stripes (gray and pink, respectively); points denote interactions called by GOTHiC. GOTHiC seemingly calls many spurious interactions. b mES CHi-C (upper panel) and 4C (lower panel) profiles centered on the bait Hoxc5 promoter are shown. The interactions called by ChiCMaxima are denoted as gray stripes, and a large number of seemingly spurious interactions called by CHiCAGO are denoted as red points. Called interactions conserved between ChiCMaxima and CHiCAGO are centered on CTCF sites. For both profiles, gene position (blue) and CTCF ChIP-seq profiles (dark green) are shown below the CHi-C and 4C profiles