Fig. 4.

ChiCMaxima performance on mES HiCap data. a mES HiCap profile centered on the Sox2 promoter. The interaction with the Sox2 enhancer called by ChiCMaxima is denoted as a gray stripe, and CHiCAGO-called interactions, including a large number of seemingly spurious ones, are denoted as red points. Gene position (blue) and selected mES ChIP-seq profiles (dark green) are shown below the HiCap profile. b Bar charts showing fold enrichment over genomic background for different ChIP-seq peaks within the promoter-interacting sequences determined by ChiCMaxima and CHiCAGO. c Overview of putative mES enhancers found within HiCap interactions called by ChiCMaxima and CHiCAGO