Table 3.
Associations between SNPs and HCC.
| Genotypes | Cases [n (%)] | Controls [n (%)] | OR (95% CI)a | P-value a | FDR | ||
|---|---|---|---|---|---|---|---|
| n | % | n | % | ||||
| rs7217395 | |||||||
| CC | 154 | 46.11 | 138 | 42.99 | 1 | - | - |
| CT | 129 | 38.62 | 137 | 42.68 | 0.97 (0.60-1.58) | 0.90 | 0.90 |
| TT | 33 | 9.88 | 26 | 8.10 | 1.41 (0.63-3.16 | 0.40 | 0.60 |
| CT/TT | 162 | 48.50 | 163 | 50.78 | 1.04 (0.66-1.65) | 0.87 | 0.89 |
| Genotyping failed | 18 | 5.39 | 20 | 6.23 | - | - | |
| rs2036316 | |||||||
| CC | 95 | 28.44 | 94 | 29.28 | 1 | - | |
| CT | 136 | 40.72 | 132 | 41.12 | 0.91 (0.52-1.57) | 0.72 | 0.90 |
| TT | 86 | 25.75 | 68 | 21.18 | 1.30 (0.70-2.42) | 0.40 | 0.60 |
| CT/TT | 222 | 66.47 | 200 | 62.31 | 1.04 (0.63-1.72) | 0.89 | 0.89 |
| Genotyping failed | 17 | 5.09 | 27 | 8.41 | - | - | |
| rs3764374 | |||||||
| CC | 214 | 64.07 | 161 | 50.16 | 1 | - | |
| CT | 101 | 30.24 | 100 | 31.15 | 1.24 (0.75-2.04) | 0.40 | 0.72 |
| TT | 16 | 4.79 | 14 | 4.36 | 0.78 (0.27-2.23) | 0.64 | 0.82 |
| CT/TT | 117 | 35.03 | 114 | 35.51 | 1.16 (0.72-1.87) | 0.53 | 0.80 |
| Genotyping failed | 3 | 0.90 | 46 | 14.33 | - | - | |
| rs1285251 | |||||||
| CC | 165 | 49.40 | 152 | 47.35 | 1 | - | |
| CT | 120 | 35.93 | 132 | 41.12 | 1.16 (0.72-1.88) | 0.55 | 0.83 |
| TT | 43 | 12.87 | 18 | 5.61 | 2.260 (0.99-5.16) | 0.05 | 0.45 |
| CT/TT | 163 | 48.80 | 150 | 46.73 | 1.31 (0.83-2.08) | 0.24 | 0.43 |
| Genotyping failed | 6 | 1.80 | 19 | 5.92 | - | - | |
| rs2289728 | |||||||
| GG | 116 | 34.73 | 88 | 27.41 | 1 | - | |
| GA | 146 | 43.71 | 152 | 47.35 | 0.56 (0.33-0.94) | 0.03 | 0.14 |
| AA | 66 | 19.76 | 64 | 19.94 | 0.63 (0.33-1.22) | 0.17 | 0.51 |
| GA/AA | 212 | 63.47 | 216 | 67.29 | 0.58 (0.35-0.94) | 0.03 | 0.23 |
| Genotyping failed | 6 | 1.80 | 17 | 5.30 | - | - | |
| rs7292074 | |||||||
| AA | 120 | 35.93 | 135 | 42.06 | 1 | - | |
| CA | 152 | 45.51 | 143 | 44.55 | 0.52 (0.25-1.07) | 0.08 | 0.24 |
| CC | 54 | 16.17 | 30 | 9.35 | 0.67 (0.33-1.36) | 0.26 | 0.59 |
| CA/CC | 206 | 61.68 | 173 | 53.89 | 1.41 (0.89-0.24 | 0.15 | 0.34 |
| Genotyping failed | 8 | 2.40 | 13 | 4.05 | - | - | |
| rs710190 | |||||||
| TT | 199 | 59.58 | 176 | 54.83 | 1 | - | |
| CT | 113 | 33.83 | 106 | 33.02 | 1.05 (0.65-1.71) | 0.84 | 0.90 |
| CC | 17 | 5.09 | 18 | 5.61 | 1.04 (0.38-2.88) | 0.94 | 0.94 |
| CT/CC | 130 | 38.92 | 124 | 38.63 | 1.05 (0.66-1.67) | 0.84 | 0.89 |
| Genotyping failed | 5 | 1.50 | 21 | 6.54 | - | - | |
| rs139394 | |||||||
| CC | 186 | 55.69 | 147 | 45.79 | 1 | - | |
| CA | 106 | 31.74 | 128 | 39.88 | 0.55 (0.33-0.90) | 0.02 | 0.14 |
| AA | 35 | 10.48 | 25 | 7.88 | 1.07 (0.47-2.43) | 0.87 | 0.94 |
| CA/AA | 141 | 42.22 | 153 | 47.66 | 0.63 (0.39-0.99) | 0.05 | 0.23 |
| Genotyping failed | 7 | 2.10 | 21 | 6.54 | - | - | |
| rs5750753 | |||||||
| CC | 82 | 24.55 | 99 | 30.84 | 1 | - | |
| CG | 158 | 47.31 | 141 | 43.93 | 1.54 (0.90-2.62) | 0.12 | 0.27 |
| GG | 86 | 25.75 | 67 | 20.87 | 1.57 (0.83-2.96) | 0.17 | 0.51 |
| CG/GG | 244 | 73.05 | 208 | 64.80 | 1.55 (0.93-2.56) | 0.09 | 0.27 |
| Genotyping failed | 8 | 2.40 | 14 | 4.36 | - | - | |
Bold values indicate statistical significance.
a: adjusted age, gender, smoking habits, alcohol intake, and HBsAg values after logistic regression. Values of these covariates in logistic regression models were shown in Table S1.