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. 2019 May 16;6:34. doi: 10.3389/fmolb.2019.00034

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Copyright © 2019 Wendler and Enenkel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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True-to-scale representation of proteasomal subcomplexes, NLS conferring adaptor proteins and nuclear transport receptors. The 20S CP, Pba1-2 bound 15S precursor complex, 19S base and 19S lid complexes are depicted with putative cNLS in α1, α4, α5, Rpn2, and Rpt2 colored in red. Importin αβ (Srp1/Kap95) binds to 20S, 15S, and 19S base complexes during nuclear import. Sts1/Cut8 binds to the 19S lid complex and possibly provides a cNLS, depicted in red, for importin αβ dependent nuclear import. Blm10 can bind to 20S and 15S complexes and possibly acts as an import receptor for nuclear transport.