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. Author manuscript; available in PMC: 2019 Sep 22.
Published in final edited form as: Nat Chem. 2019 Mar 22;11(4):342–350. doi: 10.1038/s41557-019-0230-0

Figure 1. ‘Pharmacophore–Directed Retrosynthesis’ (PDR) applied to gracilin A and comparison to other synthetic strategies harvesting the rich information content of natural products.

Figure 1

a, Strategies toward simplified, bioactive small molecules using natural products as starting points including diversity-oriented synthesis (DOS) directed toward libraries of natural product-inspired compounds. b, PDR seeks to identify or hypothesize the pharmacophore of a natural product, dictating the retrosynthesis by ensuring these features are present in multiple intermediates toward the natural product target.