FIGURE 4.

hMSC administration attenuates radiation-induced persistent CREB activation. (A) Western blots showing the activation of CREB signaling in the PLv of IR mice and partial normalization of CREB expression in IR+MSC mice. (B) Densitometric analysis of the western blots of proteins involved in CREB signaling in the PLv. Values were normalized to the GAPDH. (C) Western blots showing the activation of CREB signaling in the Hipp of IR mice and partial normalization of CREB expression in IR+MSC mice. (D) Densitometric analysis of the western blots of proteins involved in CREB signaling in the Hipp. Values were normalized to the GAPDH. (E) Schematic representation of proteins involved in CREB signaling modulation during radiation and hMSC treatment. Data are represented as mean ± SEM. n = 4–5 per group. ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, ^∗∗∗∗p < 0.0001; One-way ANOVA.