6. Comparison of antibody and RDT types verified with microscopy.
| Number of studies | Number of patients | Number of P. falciparum cases | Pooled sensitivity (95% CI) | Pooled specificity (95% CI) | Test 1 | |
| Antibody‐based test: indirect comparison (using all studies) | ||||||
| HRP‐2 based | 75 | 43,307 | 12,857 | 95.0 (93.5, 96.2) | 95.2 (93.4, 96.6) | |
| pLDH based | 19 | 14,787 | 4674 | 93.2 (88.0, 96.2) | 98.5 (96.7, 99.4) | |
| Ratio | 0.98 (0.94, 1.02), P = 0.34 | 1.03 (1.02, 1.05), P < 0.001 | P = 0.01 | |||
| Antibody‐based test: direct comparison (using only studies that directly compared the two) | ||||||
| HRP‐2 based | 9 | 10,626 | 3672 | 95.6 (90.0, 98.1) | 95.8 (84.7, 98.9) | |
| pLDH based | 9 | 10,623 | 3672 | 94.8 (84.1, 98.2) | 98.1 (87.8, 99.7) | |
| Ratio | 0.99 (0.94, 1.04) P = 0.60 | 1.02 (0.98, 1.07), P = 0.22 | P = 0.35 | |||
| Test type: indirect comparison (using all studies of Type 1 and 4) | ||||||
| Type 1 | 65 | 40,062 | 11,966 | 94.8 (93.0, 96.1) | 95.2 (93.2, 96.7) | |
| Type 4 | 16 | 1,3010 | 4274 | 91.5 (84.7, 95.3) | 98.7 (96.9, 99.5) | |
| Ratio | 0.96 (0.91, 1.02), P = 0.20 | 1.04 (1.02, 1.06), P < 0.001 | P = 0.009 | |||
| Test type: direct comparison (using only comparative studies of Type 1 and 4) | ||||||
| Type 1 | 7 | 9764 | 3433 | 94.5 (88.6, 97.4) | 95.7 (72.2, 99.5) | |
| Type 4 | 7 | 9761 | 3433 | 92.0 (85.7, 94.8) | 98.6 (80.0, 99.9) | |
| Ratio | 0.97 (0.87, 1.09), P = 0.51 | 1.03 (0.95, 1.11), P = 0.31 | P = 0.26 | |||
1Likelihood ratio test for evidence of a difference between test accuracy estimates between antigen and RDT types.