Banchongaksorn 1996a.
| Clinical features and settings |
Presenting signs and symptoms: All patients attending malaria clinics Previous treatment for malaria: No exclusions based on previous treatment. Information on previous treatment collected, but actual data not provided. Clinical setting: Two malaria clinics Country: Thailand (Tak Province and Trat province, East Thailand) Malaria endemicity: Not stated Malaria endemic species:P. falciparum andP. vivax |
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| Participants |
Sample size: 520 Age: All age groups eligible. Actual age profile of participant population not presented. Sex: Both males and females eligible. Actual proportions of males and females in the participant population not stated. Co‐morbidities and pregnancy: No exclusion criteria based on co‐morbidities or pregnancy. No details of the frequency of these conditions in the participant population is presented. Parasite density of microscopy positive cases: Not presented |
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| Study design | Enrollment was consecutive and prospective. One RDT was evaluated. | |
| Target condition and reference standard(s) |
Target condition: Malaria parasitaemia Reference standard: Microscopy thick and thin blood films Person(s) performing microscopy: Microscopist and consultant Microscopy setting: Regional and national malaria centres Number of high power fields examined before declaring negative: 100 Number of observer or repeats: Two Resolution of discrepancies between observers: Not clear, 'the data were compared and confirmed' |
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| Index and comparator tests |
Commerical name of RDT: ParaSight‐F (Beckton Dickinson, Franklin Lakes, NJ, US) Parasite(s) designed to detect:P. falciparum Designated Type: Type 1 Batch numbers: Not stated Transport and storage conditions: Not described Person(s) performing RDT: The study team RDT setting: Malaria clinics |
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| Follow‐up | Not applicable | |
| Notes | Source of funding: WHO Regional Office for South East Asia, new Delhi, India. Also Dr Joe Perrone of Becton Dickinson provided the ParaSight‐F kits | |
| Table of Methodological Quality | ||
| Item | Authors' judgement | Description |
| Representative spectrum? All tests | Yes | Participants were attending malaria clinics and therefore suspected themselves that they had malaria. It was a consecutive sample. |
| Acceptable reference standard? All tests | Yes | Two independent microscopists based at a central laboratory examined at least 100 high power fields before declaring a slide negative |
| Partial verification avoided? All tests | Yes | All participants who received the index test also received the reference test |
| Differential verification avoided? All tests | Yes | The same reference test was used regardless of the index test results |
| Incorporation avoided? All tests | Yes | The index test does not form part of the reference standard |
| Reference standard results blinded? All tests | Yes | Report states that different tests were undertaken "independently" |
| Index test results blinded? All tests | Yes | Report states that different tests were undertaken "independently" |
| Uninterpretable results reported? All tests | Unclear | Number enrolled in the study was explicitly stated and corresponded to the number presented in the analysis; therefore no withdrawals due to invalid results |
| Withdrawals explained? All tests | Yes | Number enrolled in the study was explicitly stated and corresponded to the number presented in the analysis; therefore no withdrawals |