Banchongaksorn 1997.
Clinical features and settings |
Presenting signs and symptoms: Fever over 37.5 °C by oral thermometer Previous treatment for malaria: Not mentioned, but no indication of any exclusion criteria based on previous antimalarial use Clinical setting: 34 health centres and 22 mobile health units Country: Thailand (Chiang Mai and Mae Hong Son provinces) Malaria endemicity: Not stated Malaria endemic species:P. falciparum and P. vivax |
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Participants |
Sample size: 3361 Age: All age groups eligible. Actual age profile of participant population not presented. Sex: Both males and females eligible. Actual proportions of males and females in the participant population not stated. Co‐morbidities and pregnancy: No exclusion criteria based on co‐morbidities or pregnancy. No details of the frequency of these conditions in the participant population is presented. Parasite density of microscopy positive cases: Not presented |
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Study design | Enrollment was prospective. The sampling method was not described. One RDT was evaluated. | |
Target condition and reference standard(s) |
Target condition: Malaria parasitaemia Reference standard: Microscopy thick and thin blood films Person(s) performing microscopy: Expert microscopists Microscopy setting: Malaria Regional Centre, Chiang Mai Number of high power fields examined before declaring negative: Not stated Number of observer or repeats: Not stated Resolution of discrepancies between observers: Not applicable |
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Index and comparator tests |
Commerical name of RDT: ParaSight‐F (Beckton Dickinson, Franklin Lakes, NJ, US) Parasite(s) designed to detect:P. falciparum Designated Type: Type 1 Batch numbers: Not stated Transport and storage conditions: Not described Person(s) performing RDT: Performed by health workers with 3 hours training, but results confirmed by experts at the Malaria Regional Centre RDT setting: Health centres and mobile health units |
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Follow‐up | Not applicable | |
Notes | Source of funding: Not stated | |
Table of Methodological Quality | ||
Item | Authors' judgement | Description |
Representative spectrum? All tests | Unclear | All participants were attending malaria clinics with fever, but the sampling method was not described |
Acceptable reference standard? All tests | Unclear | Microscopy was undertaken by experts at a central laboratory, but there were no details provided about the processes used |
Partial verification avoided? All tests | Yes | All participants who received the index test also received the reference test |
Differential verification avoided? All tests | Yes | The same reference test was used regardless of the index test results |
Incorporation avoided? All tests | Yes | The index test does not form part of the reference standard |
Reference standard results blinded? All tests | Yes | Microscopy was undertaken at a different location than the RDTs |
Index test results blinded? All tests | Yes | RDTs were undertaken at a different location than the microscopy |
Uninterpretable results reported? All tests | Unclear | Number of participants enrolled in the study was explicitly stated and corresponded to the number presented in the analysis; therefore there were no withdrawals due to invalid results |
Withdrawals explained? All tests | Yes | Number of participants enrolled in the study was explicitly stated and corresponded to the number presented in the analysis; therefore there were no withdrawals |