Gaye 1998.
Clinical features and settings |
Presenting signs and symptoms: Malaria symptoms Previous treatment for malaria: No exclusion criteria relating to prior antimalarial drug use. Data collected but only presented in the case of false positives. Clinical setting: Outpatient clinic Country: Senegal (Dakar) Malaria endemicity: Hypoendemic and seasonal Malaria endemic species: PredominantlyP. falciparum |
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Participants |
Sample size: 66 Age: All ages eligible. Actual age range 1 to 65 years Sex: Both males and females eligible. Actual proportions of males and females in the participant population 35 female, 31 male. Co‐morbidities and pregnancy: Not mentioned Parasite density of microscopy positive cases: Range 500 to 86,286 parasites per μl |
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Study design | Enrollment was prospective. The sampling method was not described. Three RDTs were evaluated and all participants received all three tests. | |
Target condition and reference standard(s) |
Target condition: Malaria parasitaemia Reference standard: Microscopy thick blood film Person(s) performing microscopy: Not stated Microscopy setting: Not stated Number of high power fields examined before declaring negative: Not stated Number of observer or repeats: Not stated Resolution of discrepancies between observers: Not applicable |
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Index and comparator tests |
Commerical name of RDT: ICT Malaria Pf (ICT Diagnostics, Sydney, Australia) ParaSight‐F (Beckton Dickinson, Franklin Lakes, NJ, US) Malaria IgG CELISA (CelLabs Sydney, Australia) (excluded as not eligible for inclusion in this review) Parasite(s) designed to detect:P. falciparum Designated Type: Type 1 Batch numbers: Not stated Transport and storage conditions: Not described Person(s) performing RDT: Not stated RDT setting: Not stated |
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Follow‐up | Not applicable | |
Notes | Source of funding: Not stated | |
Table of Methodological Quality | ||
Item | Authors' judgement | Description |
Representative spectrum? All tests | Unclear | All participants were presenting to an outpatient clinic with malaria symptoms, but the sampling method was not described |
Acceptable reference standard? All tests | Unclear | No details given of the microscopy process |
Partial verification avoided? All tests | Yes | All participants who received the index test also received the reference test |
Differential verification avoided? All tests | Yes | The same reference test was used regardless of the index test results |
Incorporation avoided? All tests | Yes | The index test does not form part of the reference standard |
Reference standard results blinded? All tests | Unclear | Blinding not described |
Index test results blinded? All tests | Unclear | Blinding not described |
Uninterpretable results reported? All tests | Unclear | The numbers of participants originally enrolled in the study was clearly stated, and corresponds to the number presented in the analysis; therefore there were no exclusions due to invalid test results |
Withdrawals explained? All tests | Yes | The numbers of participants originally enrolled in the study was clearly stated, and corresponds to the number presented in the analysis; therefore there were no withdrawals |