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. 2011 Jul 6;2011(7):CD008122. doi: 10.1002/14651858.CD008122.pub2

Mendiratta 2006.

Clinical features and settings Presenting signs and symptoms: Clinically suspected to be suffering from malaria
Previous treatment for malaria: No exclusions based on previous treatment, and no data presented on previous use of antimalarials, except for retrospective analysis in the case of false positive results
Clinical setting: Not clear
Country: Sevagram, India
Malaria endemicity: Not stated
Malaria endemic species:P. falciparum
Participants Sample size: 443
Age: Age profile of participant population not presented. Does not mention age as inclusion criteria.
Sex: Both males and females eligible. Actual proportions of males and females in the participant population not stated.
Co‐morbidities and pregnancy: No exclusion criteria based on co‐morbidities or pregnancy. No details of the frequency of these conditions in the participant population presented.
Parasite density of microscopy positive cases: Not presented
Study design Enrollment was consecutive and prospective. One RDT was evaluated.
Target condition and reference standard(s) Target condition: Malaria parasitaemia
Reference standard: Microscopy thick and thin blood films
Person(s) performing microscopy: Experienced microscopists
Microscopy setting: Department of Microbiology, Mahatma Ghandi Institute of Medical Sciences, Sevagram
Number of high power fields examined before declaring negative: Not stated
Number of observer or repeats: Two independent observers
Resolution of discrepancies between observers: Not described
Index and comparator tests Commerical name of RDT: Paracheck Pf (Orchid Biomedical Systems, Goa, India)
Parasite(s) designed to detect:P. falciparum
Designated Type: Type 1
Batch numbers: Not stated
Transport and storage conditions: Not described
Person(s) performing RDT: Not stated
RDT setting: Department of Microbiology, Mahatma Ghandi Institute of Medical Sciences, Sevagram
Follow‐up Not applicable
Notes Source of funding: Not stated
Table of Methodological Quality
Item Authors' judgement Description
Representative spectrum? 
 All tests Unclear Participants were a consecutive sample of people with fever and clinically suspected malaria; however the setting is unclear
Acceptable reference standard? 
 All tests Unclear Microscopy undertaken by two trained microscopists, but it is was not stated how many high power fields they viewed before declaring a slide negative
Partial verification avoided? 
 All tests Yes All participants who received the index test also received the reference test
Differential verification avoided? 
 All tests Yes The same reference test was used regardless of the index test results
Incorporation avoided? 
 All tests Yes The index test does not form part of the reference standard
Reference standard results blinded? 
 All tests Unclear Blinding not described
Index test results blinded? 
 All tests Unclear Blinding not described
Uninterpretable results reported? 
 All tests Unclear The number of participants originally enrolled in the study was clearly stated, and corresponded to the number presented in the analysis; therefore there were no exclusions due to invalid test results
Withdrawals explained? 
 All tests Yes The number of participants originally enrolled in the study was clearly stated, and corresponded to the number presented in the analysis; therefore there were no withdrawals