Mendiratta 2006.
Clinical features and settings |
Presenting signs and symptoms: Clinically suspected to be suffering from malaria Previous treatment for malaria: No exclusions based on previous treatment, and no data presented on previous use of antimalarials, except for retrospective analysis in the case of false positive results Clinical setting: Not clear Country: Sevagram, India Malaria endemicity: Not stated Malaria endemic species:P. falciparum |
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Participants |
Sample size: 443 Age: Age profile of participant population not presented. Does not mention age as inclusion criteria. Sex: Both males and females eligible. Actual proportions of males and females in the participant population not stated. Co‐morbidities and pregnancy: No exclusion criteria based on co‐morbidities or pregnancy. No details of the frequency of these conditions in the participant population presented. Parasite density of microscopy positive cases: Not presented |
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Study design | Enrollment was consecutive and prospective. One RDT was evaluated. | |
Target condition and reference standard(s) |
Target condition: Malaria parasitaemia Reference standard: Microscopy thick and thin blood films Person(s) performing microscopy: Experienced microscopists Microscopy setting: Department of Microbiology, Mahatma Ghandi Institute of Medical Sciences, Sevagram Number of high power fields examined before declaring negative: Not stated Number of observer or repeats: Two independent observers Resolution of discrepancies between observers: Not described |
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Index and comparator tests |
Commerical name of RDT: Paracheck Pf (Orchid Biomedical Systems, Goa, India) Parasite(s) designed to detect:P. falciparum Designated Type: Type 1 Batch numbers: Not stated Transport and storage conditions: Not described Person(s) performing RDT: Not stated RDT setting: Department of Microbiology, Mahatma Ghandi Institute of Medical Sciences, Sevagram |
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Follow‐up | Not applicable | |
Notes | Source of funding: Not stated | |
Table of Methodological Quality | ||
Item | Authors' judgement | Description |
Representative spectrum? All tests | Unclear | Participants were a consecutive sample of people with fever and clinically suspected malaria; however the setting is unclear |
Acceptable reference standard? All tests | Unclear | Microscopy undertaken by two trained microscopists, but it is was not stated how many high power fields they viewed before declaring a slide negative |
Partial verification avoided? All tests | Yes | All participants who received the index test also received the reference test |
Differential verification avoided? All tests | Yes | The same reference test was used regardless of the index test results |
Incorporation avoided? All tests | Yes | The index test does not form part of the reference standard |
Reference standard results blinded? All tests | Unclear | Blinding not described |
Index test results blinded? All tests | Unclear | Blinding not described |
Uninterpretable results reported? All tests | Unclear | The number of participants originally enrolled in the study was clearly stated, and corresponded to the number presented in the analysis; therefore there were no exclusions due to invalid test results |
Withdrawals explained? All tests | Yes | The number of participants originally enrolled in the study was clearly stated, and corresponded to the number presented in the analysis; therefore there were no withdrawals |