Comparison 1. Arteether versus quinine.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Death	2	194	Risk Ratio (M‐H, Fixed, 95% CI)	0.75 [0.43, 1.30]
2 Neurological complications at follow up	1	58	Risk Ratio (M‐H, Fixed, 95% CI)	1.18 [0.31, 4.46]
3 Time to regain consciousness (hours)	2	153	Mean Difference (IV, Fixed, 95% CI)	6.69 [‐3.19, 16.57]
4 Parasite clearance time (hours)	2	152	Mean Difference (IV, Fixed, 95% CI)	1.32 [‐6.48, 9.11]
5 Presence of parasites at day 7	2	151	Risk Ratio (M‐H, Fixed, 95% CI)	0.57 [0.19, 1.67]
6 Presence of parasites at day 28	1	78	Risk Ratio (M‐H, Fixed, 95% CI)	0.76 [0.39, 1.49]
7 Fever clearance time (hours)	2	146	Mean Difference (IV, Fixed, 95% CI)	5.10 [‐5.76, 15.95]
8 People with any adverse events	1	92	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.77, 1.22]
9 People with serious adverse events	1	102	Risk Ratio (M‐H, Fixed, 95% CI)	0.33 [0.01, 8.00]