Thuma 2000.

Methods	Trial design: randomized controlled trial Generation of allocation sequence: computer‐generated block randomization Allocation concealment: sealed, coded envelopes Blinding: none as different routes of drug administration used Loss to follow up: none
Participants	92 male and female children aged 0 to 10 with cerebral malaria: 3/95 (3%) excluded; 92 evaluated (arteether (48), quinine (44)) Inclusion criteria: asexual falciparum parasitaemia; Blantyre coma score of 2 or less with no other cause for coma Exclusion criteria: history of chronic illness and blackwater fever
Interventions	1. Arteether (Artemotil) for 5 days (3.2 mg/kg first day, then 1.6 mg/kg next 4 days) 2. Quinine for 7 days (20 mg/kg loading dose, then 10 mg/kg thereafter)
Outcomes	1. Mortality 2. Parasite clearance time 3. Fever clearance time 4. Coma resolution time 5. Residual neurological sequelae 6. Adverse events
Notes	Location: Zambia