Krishna 1995a.

Methods	Randomized, unblinded, method of randomization not stated. Concealment of allocation unclear. Losses to follow‐up not clearly stated but calculated to be 5 (23.8%), since final report of FCT and PCT indicated that n=16 out of 21. No intention‐to‐treat analysis. The study was approved by the ethical review subcommittee of the Ministry of Health, Tanzania. The study was a component of Wellcome‐ Mahidol University‐ Oxford Tropical Medicine Research Programme.
Participants	14 patients were included out of 21 adults (7 per group). All had uncomplicated P. falciparum malaria. Kanchanaburi, Thailand Oral temperature > 38 ºC Range of parasitaemia: 1130 to 24,9600/µL Exclusion criteria: age < 14 years, pregnancy, paracetamol taken < 6 hours before
Interventions	Group A: Quinine (10 mg/kg, oral) followed 2 hours later by paracetamol (15 mg/kg, oral) Group B: Paracetamol (15 mg/kg) followed 2 hours later by quinine (10 mg/kg) Group C: Quinine (10 mg/kg) with no paracetamol Group A was excluded from review
Outcomes	Mean maximal fall in temp in 6 hours Time taken for temp to drop to < 38 ºC FCT PCT Cure rate Blood levels of paracetamol
Notes	—
Risk of bias
Bias	Authors' judgement	Support for judgement
Blinding (performance bias and detection bias) All outcomes	High risk
Incomplete outcome data (attrition bias) All outcomes	Low risk
Selective reporting (reporting bias)	Low risk