| Study | Reason for exclusion |
|---|---|
| Bejon 2005 | Nonrandomized review and methodology study |
| Doherty 1999 | Nonrandomized study |
| Edelman 2002 | Nonrandomized study |
| Epstein 2004 | Nonrandomized study |
| Fries 1992 | Nonrandomized study |
| Gordon 1990 | Nonrandomized study |
| Gordon 1995 | Nonrandomized study |
| Heppner 1996 | Nonrandomized study |
| Hoffman 1994 | 2 groups with very small numbers of participants, and only 1 group randomized |
| Hoffman 2002 | Nonrandomized study |
| Le 1999 | Nonrandomized open label dose‐finding safety and immunogenicity study |
| McConkey 2003 | Nonrandomized immunogenicity study |
| Moorthy 2003 | Nonrandomized safety and immunogenicity study; no placebo group |
| Moorthy 2004c | Quasi‐randomized safety and immunogenicity study; no placebo group |
| Nardin 2000 | Nonrandomized immunogenicity study |
| Nardin 2001 | Nonrandomized immunogenicity study |
| Roggero 1999 | Nonrandomized study |
| Stoute 1998 | Participants were randomized between different doses of the vaccine, but not randomized between vaccine and control groups |
| Walther 2005 | Nonrandomized study |
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