Del Brutto 1999.

Methods	Randomized controlled trial Duration: dates not specified
Participants	Number: 20 enrolled (8 male, 12 female) Inclusion criteria: adults with less than 20 parenchymal brain cysts with no evidence of surrounding inflammation Exclusion criteria: mixed forms of the disease Type of lesion: viable
Interventions	Group 1. Albendazole: 15 mg per kg for 7 days plus prednisolone 1 mg per kg bodyweight per day, until a few days after the end of the trial Group 2. Praziquantel: 100 mg per kg bodyweight for 1 day, plus 2 mg doses of intravenous dexamethasone administered 6 and 8 hours after the last dose of praziquantel
Outcomes	Included in the review: number of cysts at baseline and 3 months; persistence of cysts at 3 months; persistence of seizures at 6 to 12 months; adverse events associated with treatment Not included in the review: improvement in motor deficit at 6 to 12 months
Notes	Location: Ecuador Source of funding: not stated
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Low risk	Quote: "...patients were randomly allocated (from a table of random numbers) to one of two treatment groups" Decision: done
Allocation concealment?	Unclear risk	Not described Decision: unclear
Blinding? All outcomes	Low risk	Quote: "All CT studies were independently reviewed by two experienced radiologists, blinded to the therapy used..." Decision: done
Incomplete outcome data addressed? All outcomes	Low risk	20 participants randomized, all 20 followed up to 6 months (100%)
Free of selective reporting?	Low risk	No evidence of selective reporting
Free of other bias?	Low risk	No evidence of other bias