Gongora‐Rivera 2006.
Methods | Randomized controlled trial Duration: between November 1999 and January 2001 |
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Participants | Number: 36 enrolled (14 male, 22 female) Inclusion criteria: adults with subarachnoid and intraventricular cysticercosis Exclusion criteria: concurrent disease that contraindicated corticosteroid, albendazole allergy, previous cysticidal or surgical treatment for neurocysticercosis in the previous 3 months, pregnant or lactating women, neurological diseases affecting function, unable to attend for regular follow up, Karnofsky score ≤ 50 points Type of lesion: degenerating, viable, or mixed |
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Interventions | Group 1. Intravenous dexamethasone: 8 mg every 8 hours for 4 days followed by 15 mg per kg albendazole for 1 day Group 2. Intravenous dexamethasone: 8 mg every 8 hours for 4 days followed by 30 mg per kg albendazole for 1 day | |
Outcomes | Included in the review: symptom severity score at baseline and 7 days; adverse events associated with treatment Not included in the review: reduction in cyst volume at 90 days |
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Notes | Location: Mexico Source of funding: not stated |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Adequate sequence generation? | Low risk | Quote: "...a computer‐generated randomization plan" Decision: done |
Allocation concealment? | Low risk | Quote: "The code of the two different albendazole doses was available in sealed envelopes and was not opened until the trial completion" |
Blinding? All outcomes | Low risk | Quote: "For blinding the pharmaceutical laboratory...provided according to a computer‐generated randomization plan, tablets containing 200 mg or 400 mg albendazole with identical appearance. Neither the patient nor the study staff were aware of treatment assignment" Decision: done |
Incomplete outcome data addressed? All outcomes | Low risk | Inclusion of randomized participants in the analysis: 36 randomized, 5 did not compete the study (86%). An intention‐to‐treat analysis was also undertaken with similar results obtained. |
Free of selective reporting? | Low risk | No evidence of selective reporting |
Free of other bias? | Low risk | No evidence of other bias |