Trial  country	Treatment regimen	Blind ing	Total failure	Comparison	Risk ratio (95% CI) (or P‐value if 0 failures)	Cure day 28 (95% CI)
	P. vivax
Dunne 2005A India	1) Azithromycin 1 g/day for 3 days	P	12/97	1 vs. 2	12.62 (1.67‐95.22)	88 (79‐93)
	2) Chloroquine 0.6 g on day 1 to 2, 0.3 g on day 3	P	1/102			99 (94‐100)
Pukrittayakamee 2001 Thailand	1) Azithromycin 0.5 g/day for 3 days	O	10/18			44 (22‐69)§
	2) Tetracycline 250 mg 4x/day for 7 days	O	4/18	1 vs. 2	2.50 (0.96‐6.52)	78 (52‐93)§
	3) Doxycycline 200 mg/day for 7 days	O	8/18	1 vs. 3	1.25 (0.65‐2.42)	56 (31‐78)§
	4) Clindamycin 300 mg 4x/day for 7 days	O	5/12	1 vs. 4	1.33 (0.61‐2.93)	58 (29‐84)§
	P. falciparum
Dunne 2005B India	1) Azithromycin 1 g/day for 3 days	P	9/14	1 vs. 2	0.88 (0.53‐1.44)	36 (14‐64)
	2) Chloroquine 0.6 g on day 1 to 2, 0.3 g on day 3	P	11/15	3 vs. 2 ¶	0.04 (0.01‐0.18)	27 (9‐55)
	3) Azithromycin 1 g/day for 3 days, chloroquine 0.6 g on day 1 to 2, 0.3 g on day 3	O	2/63	3 vs. 1 ¶	0.05 (0.01‐0.20)	97 (88‐99)
Krudsood 2000 Thailand	1) Azithromycin 0.5 g/day, artesunate 200 mg/day for 3 days	O	24/55			56 (42‐69)§
	2) Artesunate 200 mg/day for 3 days, mefloquine 10 mg/kg on day 1 to 2, 5 mg/kg on day 3	O	1/55	1 vs. 2	24.00 (3.36‐171.27)	98 (89‐100)§
	3) Artesunate 200 mg/day for 3 days	O	34/61	1 vs. 3	0.78 (0.54‐1.14)	44 (32‐57)§
Miller 2006 Thailand	1) Azithromycin 0.5 g 2x/day and quinine 10 mg/kg 3x/day for 3 days	O	1/10	1 vs. 2 1 vs. 3 ¶ 1 vs. 4	P=0.33 (Fisher) P=0.33 (Fisher) P=1.0 (Fisher)	90 (54‐99)*
	2) Azithromycin 0.5 g 2x/day and quinine 10 mg/kg 3x/day for 5 days	O	0/20	2 vs. 1 2 vs. 3 ¶ 2 vs. 4	P=0.33 (Fisher) P=1.0 (Fisher) P=1.0 (Fisher)	100 (80‐100)
	3) Azithromycin 0.5 g 3x/days and quinine 10 mg/kg 3x/day for 3 days	O	0/20	3 vs. 1 ¶ 3 vs. 2 ¶ 3 vs. 4 ¶	P=0.33 (Fisher) P=1.0 (Fisher) P=1.0 (Fisher)	100 (80‐100)
	4) Doxycycline 100 mg 2x/day and quinine 10 mg/kg 3x/day for 7 days	O	0/10			100 (66‐100)
Na‐Bangchang 1996 Thailand	1) Azithromycin 0.5 g at start, 0.25 g at 24 and 48 hrs, and artemether 300 mg at start	O	23/27	1 vs. 2	1.83 (1.21‐2.76)	15 (5‐35)
	2) Doxycycline 100 mg 2x/day for 5 days and artemether 300 mg at start and 100 mg after 12 hours	O	14/30			53 (35‐71)
Noedl 2006 Thailand	1) Azithromycin 0.75 g 2x/day and artesunate 100 mg 2x/day for 3 days	O	2/25	1 vs. 2 1 vs. 3 1 vs. 4	0.72 (0.13‐3.96) 0.30 (0.06‐1.44) 1.00 (0.15‐6.55)	92 (73‐99)§
	2) Azithromycin 1 g/day and artesunate 200 mg/day for 3 days	O	3/27	2 vs. 1 2 vs. 3 2 vs. 4	1.39 (0.25‐7.64) 0.42 (0.11‐1.62) 1.39 (0.25‐7.64)	89 (70‐97)§
	3) Azithromycin 0.75 g 2x/day and quinine 10 mg/kg 2x/day for 3 days	O	4/15	3 vs. 1 3 vs. 2 3 vs. 4	3.33 (0.69‐16.06) 2.40 (0.62‐9.33) 3.33 (0.69‐16.06)	73 (45‐91)§
	4) Azithromycin 0.5 g 3x/day and quinine 10 mg/kg 3x/day for 3 days	O	2/25	4 vs. 1 4 vs. 2 4 vs. 3	1.00 (0.15‐6.55) 0.72 (0.13‐3.96) 0.30 (0.06‐1.44)	92 (73‐99)§
Pfizer74841 India	1) Azithromycin 1 g/day and chloroquine 0.6 g/day for 3 days	P/O	12/73	1 vs. 2 1 vs. 3	0.48 (0.26‐0.91) 2.96 (1.00‐8.75)	84 (73‐91)
	2) Azithromycin 0.5 g/day and chloroquine 0.6 g/day for 3 days	P	20/59	2 vs. 1 2 vs. 3	2.06 (1.10‐3.86) 6.10 (2.21‐16.87)	66 (53‐78)
	3) Sulfadoxine‐pyrimethamine 1500 mg/75 mg at start, chloroquine 600 mg on day 1 to 2, 300 mg on day 3	O	4/72			94 (86‐98)
Pfizer 82563 Kenya	1) Azithromycin 1 g/day and chloroquine 0.6 g/day for 3 days	P	1/5	1 vs. 2	0.70 (0.09‐5.76)	80 (30‐99)
	2) Chloroquine 0.6 g/day for 3 days	P	2/7			86 (42‐99)*
Pfizer 82576 Ghana, Kenya, Mali, Uganda, Zambia	1) Azithromycin 1 g/day and chloroquine 0.6 g/day for 3 days	P	5/103	1 vs. 3	2.50 (0.50‐12.59)	98 (92‐100)*
	2) Azithromycin 0.5 g/day and chloroquine 0.6 g/day for 3 days	P	NR
	3) Mefloquine 750 mg at start, 500 mg after 6 hours	P	2/103			99 (94‐100)*
Pfizer 84227 Colombia/Surinam	1) Azithromycin 1 g/day and chloroquine 0.6 g/day for 3 days	P	48/112	1 vs. 3	48.43 (6.80‐344.84)	61 (51‐70)**
	2) Azithromycin 0.5 g/day and chloroquine 0.6 g/day for 3 days	P	NR
	3) Atovaquone 1000 mg/day and proguanil 400 mg/day for 3 days	P	1/113			100 (96‐100)*
Pfizer 84240 Indonesia	1) Azithromycin 1 g/day and chloroquine 0.6 g/day for 3 days	P	9/13	1 vs. 3	2.31 (0.84‐6.36)	31 (10‐61)**
	2) Azithromycin 0.5 g/day and chloroquine 0.6 g/day for 3 days	P	NR
	3) Sulfadoxine‐pyrimethamine 1500 mg/75 mg at start, chloroquine 0.6 g on day 1 to 2, 0.3 g on day 3	P	3/10			80 (44‐96)*
Pfizer 367653 Burkina Faso, Ghana, Kenya, Mali, Senegal, Zambia	1) Azithromycin 1 g/day and chloroquine 0.6 g/day for 3 days	O	1/107	1 vs. 2	1.05 (0.07‐16.52)	100 (96‐100)*
	2) Mefloquine 750 mg at start, 500 mg after 6to 10 hours	O	1/112			99 (94‐100)*
Sykes 2009 Tanzania	1) Azithromycine 20 mg/kg/day and artesunate 4 mg/kg/day for 3 days	O	69/119	1 vs. 2	2.90 (1.96‐4.28)	66 (57‐75)**
	2) Artemether 20 mg and lumefantrine 120 mg 2x/day for < 15 kg and 40 mg/240 mg 2x/day for ≥15 kg for 3 days	O	24/120			90 (93‐95)**
Thriemer 2010 Bangladesh	1) Azithromycin 1.5 g/day and artesunate 200 mg/day for 3 days. Children < 35 kg: azithromycin 30 mg/kg/day, and artesunate 4 mg/kg/day for 3 days.	O	13/142	1 vs. 2	6.32 (0.84‐47.31)	94 (89‐97)*
	2) Artemether 80 mg and lumefantrine 480 mg 2x/day for 3 days. Children < 35 kg: artemether 4 mg/kg and lumefantrine 24 mg/kg 2x/day for 3 days	O	1/69			100 (93‐100)*
	Excluded studies (P. falciparum)
Krudsood 2002 Thailand	1) Azithromycin 0.5 g/day and dihydroartemisinin 80 mg/day for 3 days	O	46/66	1 vs. 2	P < 0.001 (Fisher)	70 (57‐80)§
	2) Mefloquine 10 mg/kg on day 1 and 2, and 5 mg/kg on day 3, and dihydroartemisinin 80 mg/day for 3 days	O	0/68			100 (93‐100)§
Pfizer 282918 India, Colombia	1) Azithromycin 2 g/day and chloroquine 600 mg/day for 3 days	O	5/107			97 (91‐99)*