Study	Definition	Treatment	N	Median, hrs	Mean (SD), hrs	Range, hrs
	P. vivax
Dunne 2005a	Time to clearance of parasitaemia	AZ	97	55		NR
		CQ	102	20		NR
Pukrittayakamee 2001	Time to fall below detectable levels in a peripheral blood smear.	AZ	20		146 (65)
		TET	27		131 (35)
		DX	25		145 (45)
		CL	20		110 (42)
	P. falciparum
Dunne 2005b	Time at resolution of parasitaemia	AZ	16	96		NR
		CQ	16	57		NR
		AZ/CQ	63	36		NR
Krudsood 2000	Time from the start of treatment until the first negative blood film, which remained negative for the next 24 hours	AZ+AT	67		43.5 (17.3)	5‐103
		AT+MQ	67		45.3 (14.7)	11‐97
		AT	68		43.7 (13.6)	21‐80
Miller 2006	Time from the start of treatment until the first negative blood smear for asexual stages, which remained negative for an additional 24 hours	AZ3+Q	10		78.9 (25.8)	‐
		AZ5+Q	20		77.7 (21.4)	‐
		AZ4.5+Q	20		77.7 (23.1)	‐
		Q+DX	10		68.8 (23.1)	‐
Na‐Bangchang 1996	Time taken for the parasite count to fall below the level of microscopic detection	ART+AZ	27	28		18‐48
		ART+DX	30	31		8‐54
Noedl 2006	Time from initiation of treatment until the first time that blood films were negative for asexual parasites of P. falciparum and remained negative for the next 48 hours	AZ4.5+AT	25		33.1 (15.3)	8.8‐79.1
		AZ3+AT	27		35.7 (10.5)	18.2‐55.6
		AZ4.5+60Q	15		93.1 (32.0)	37.0‐149.1
		AZ4.5+90Q	25		62.9 (26.1)	14.5‐115.5
Thriemer 2010	The interval from the start of the treatment until the first time a blood smear was negative for asexual P. falciparum and two consecutive smears were negative.	AZ4.5+AT	128	25.1		IQR 18.5‐30.3
		AL	65	27.2		18.3‐30.2