Trial  country	Treatment regimen	Blinding	AE treatment related (TR) (%)	Risk ratio AE*   (95% CI)	AE any cause (AC) (%)	Number AE
						TR (average AE/person)	AC (average AE/person)
	P. vivax
Dunne 2005A India	1) Azithromycin 1 g/day for 3 days	P	13/97 (13.4)	0.57 (0.31‐1.05)		15/97 (0.2)
	2) Chloroquine 0.6 g on day 1 to 2, 0.3 g on day 3	P	24/102 (23.5)	Reference		35/102 (0.3)
Pukrittayakamee 2001 Thailand	1) Azithromycin 0.5 g/day for 3 days	O	6/18 (33.3)^	P = 0.06 (Fisher)
	2) Tetracycline 250 mg 4x/day for 7 days	O	0/18 (0.0)
	3) Doxycycline 200 mg/day for 7 days	O	0/18 (0.0)
	4) Clindamycin 300 mg 4x/day for 7 days	O	0/12 (0.0)	Reference
	P. falciparum
Dunne 2005B India	1) Azithromycin 1 g/day for 3 days	P	8/16 (50.0)	0.78 (0.42‐1.46)		8/16 (0.5)
	2) Chloroquine 0.6 g on day 1 to 2, 0.3 g on day 3	P	9/16 (56.3)	Reference		10/16 (0.6)
	3) Azithromycin 1 g/day for 3 days, chloroquine 0.6 g on day 1 to 2, 0.3 g on day 3	O	13/63 (20.6)	0.37 (0.19‐0.70)		18/63 (0.3)
Krudsood 2000 Thailand	1) Azithromycine 0.5 g/day, Artesunate 200 mg/day for 3 days	O	NR	"Most adverse events were mild to moderate severity, difficult to distinguish from complaints of malaria, and disappeared within a week after the drugs were administered."
	2) Artesunate 200 mg/day for 3 days, mefloquine 10 mg/kg on day 1 to 2, 5 mg/kg on day 3	O	NR
	3) Artesunate 200 mg/day for 3 days	O	NR
Miller 2006 Thailand	1) Azithromycin 0.5 g 2x/day and quinine 10 mg/kg 3x/day for 3 days	O	10/10 (100)			16/10 (1.6)	32/10 (3.2)
	2) Azithromycin 0.5 g 2x/day and quinine 10 mg/kg 3x/day for 5 days	O	20/20 (100)			28/20 (1.4)	45/20 (2.3)
	3) Azithromycin 0.5 mg 3x/day and quinine 10 mg/kg 3x/day for 3 days	O	21/21 (100)			32/21 (1.5)	55/21 (2.6)
	4) Doxycycline 100 mg 2x/day and quinine 10 mg/kg 3x/day for 7 days	O	10/10 (100)			20/10 (2.0)	31/10 (3.1)
Na‐Bangchang 1996 Thailand	1) Azithromycin 0.5 g at start, 0.25 g at 24 hours and 48 hours, and artemether 300 mg at start	O	NR	0.28 (0.09‐0.88)	3/27 (11.1)
	2) Doxycycline 100 mg 2x/day for 5 days and artemether 300 mg at start and 100 mg after 12 hours	O	NR	Reference	12/30 (40.0)
Noedl 2006 Thailand	1) Azithromycin 0.75 g 2x/day and artesunate 100 mg 2x/day for 3 days	O	1/27 (3.7)	0.05 (0.01‐0.37)	26/27 (96.3)		113/27(4.2)
	2) Azithromycin 1 g/day and artesunate 200 mg/day for 3 days	O	3/27 (11.1)	0.16 (0.05‐0.47)	27/27 (100)		154/27 (5.7)
	3) Azithromycin 0.75 g 2x/day and quinine 10 mg/kg 2x/day for 3 days	O	8/16 (50.0)	0.71 (0.41‐1.23)	16/16 (100)		102/16 (6.4)
	4) Azithromycin 0.5 g 3x/day and quinine 10 mg/kg 3x/day for 3 days	O	19/27 (70.4)	Reference	27/27 (100)		169/27 (6.3)
Pfizer74841^^ India	1) Azithromycin 1 g/day and chloroquine 0.6 g/day for 3 days	P/O	NR			7/83 (0.1)	24/83 (0.3)
	2) Azithromycin 0.5 g/day and chloroquine 0.6 g/day for 3 days	P	NR			2/67 (0.03)	20/67 (0.3)
	3) Sulfadoxine‐pyrimethamine 1500 mg/75 mg at start, chloroquine 600 mg on day 1 to 2, 300 mg on day 3	O	NR			3/80 (0.04)	22/80 (0.3)
Pfizer 82563 Kenya	1) Azithromycin 1 g/day and chloroquine 0.6 g/day for 3 days	P			7/7 (100)	7/7 (1.0)
	2) Chloroquine 0.6 g/day for 3 days	P			7/7 (100)	18/7 (2.6)
Pfizer 82576 Ghana, Kenya, Mali, Uganda, Zambia	1) Azithromycin 1 g/day and chloroquine 0.6 g/day for 3 days	P	89/114 (78.1)	1.26 (1.06‐1.50)	106/114 (93.0)	175/114 (1.5)	327/114 (2.9)
	2) Azithromycin 0.5 g/day and chloroquine 0.6 g/day for 3 days	P	4/9 (44.4)	0.72 (0.34‐1.52)	6/9 (66.7)	7/9 (0.8)	11/9 (1.2)
	3) Mefloquine 750 mg at start, 500 mg after 6 hours	P	71/115 (61.7)	Reference	107/115 (93.0)	150/115 (1.3)	337/115 (2.9)
Pfizer 84227^^ Colombia/Surinam	1) Azithromycin 1 g/day and chloroquine 0.6 g/day for 3 days	P	NR	1.41 (1.09‐1.83)	68/114 (59.6)
	2) Azithromycin 0.5 g/day and chloroquine 0.6 g/day for 3 days	P	NR	1.52 (0.98‐7.80)	9/14 (64.3)
	3) Atovaquone 1000 mg/day and proguanil 400 mg/day for 3 days	P	NR	Reference	49/116 (42.2)
Pfizer 84240 Indonesia	1) Azithromycin 1 g/day and chloroquine 0.6 g/day for 3 days	P	8/13 (61.5)	1.48 (0.67‐3.27)	10/13 (76.9)	22/13 (1.7)	46/13 (3.5)
	2) Azithromycin 0.5 g/day and chloroquine 0.6 g/day for 3 days	P	6/7 (85.7)	2.06 (0.99‐4.29)	7/7 (100)	12/7 (1.7)	26/7 (3.7)
	3) Sulfadoxine‐Pyrimethamine 1500mg /75 mg at start, chloroquine 0.6 g on day 1 to 2, 0.3 g on day 3	P	5/12 (41.7)	Reference	7/12 (58.3)	8/12 (0.7)	18/12 (1.5)
Pfizer 367653 Burkina Faso, Ghana, Kenya, Mali, Senegal, Zambia	1) Azithromycin 1 g/day and chloroquine 0.6 g/day for 3 days	O	80/113 (70.8)	1.14 (0.95‐1.37)	95/113 (84.1)	173/113 (1.5)	264/113 (2.3)
	2) Mefloquine 750 mg at start, 500 mg after six to10 hours	O	72/116 (62.1)	Reference	92/116 (79.3)	175/116 (1.5)	281/116 (2.4)
Sykes 2009 Tanzania	1) Azithromycine 20 mg/kg/day and artesunate 4 mg/kg/day for 3 days	O		1.21 (0.81‐1.80)	39/129 (30.2)		44/129 (0.3)
	2) Artemether 20 mg and lumefantrine 120 mg 2x/day for < 15 kg and 40 mg/240 mg 2x/day for ≥15 kg for 3 days	O		Reference	33/132 (25.0)		38/132 (0.3)
Thriemer 2010 Bangadesh	1) Azithromycin 1.5 g/day and artesunate 200 mg/day for 3 days. Children <35 kg: azithromycin 30 mg/kg/day, and artesunate 4 mg/kg/day for 3 days.	O					27/128 (0.2)
	2) Artemether 80 mg and lumefantrine 480 mg 2x/day for 3 days. Children <35 kg: artemether 4 mg/kg and lumefantrine 24 mg/kg 2x/day for 3 days	O					33/65 (0.5)
	Excluded studies (P. falciparum)
Krudsood 2002 Thailand	1) Azithromycin 0.5 g/day and dihydroartemisinin 80 mg/day for 3 days	O	NR	"Regarding safety, it was difficult to distinguish between symptoms of acute malaria and drug‐related effects. All signs and symptoms and parasitaemia simultaneously disappeared within few days."
	2) Mefloquine 10 mg/kg on day 1 and 2, and 5 mg/kg on day 3, dihydroartemisinin 80 mg/day for 3 days
Pfizer 282918 India, Colombia	1) Azithromycin 2 g/day and chloroquine 0.6 g/day for 3 days	O	48/110 (43.6)		NR	78/110 (0.7)