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. 2011 Feb 16;2011(2):CD006688. doi: 10.1002/14651858.CD006688.pub2
Study Treatment regimes Blinding Nausea Vomiting Diarrhoea Pruritis Dizziness
% n/N % n/N % n/N % n/N % n/N
Dunne 2005a
India		 1) AZ 1 g/day for 3 days P 0.0 0/97 0.0 0/97 0.0 0/97 1.0 1/97 NR  
2) CQ 0.6 g on day 1 to 2, 0.3 g on day 3 P 4.9 5/102 7.8 8/102 0.0 0/102 7.8 8/102 NR  
Dunne 2005b
India		 1) AZ 1 g/day for 3 days P 0.0 0/16 0.0 0/16 12.5 2/16 6.3 1/16 6.3 1/16
2) CQ 0.6 g on day 1 to 2, 0.3 g on day 3 P 0.0 0/16 0.0 0/16 6.3 1/16 18.8 3/16 18.8 3/16
3) AZ 1 g/day for 3 days, CQ 0.6 mg on day 1 to 2, 0.3 g on day 3 O 6.3 4/63 7.9 5/63 3.2 2/63 1.6 1/63 0.0 0/63
Miller 2006
Thailand		 1) AZ 0.5 g 2x/day and quinine 10 mg/kg 3x/day for 3 days O NR   10.0 1/10 20.0 2/10 NR   100.0 10/10
2) AZ 0.5 g 2x/day and quinine 10 mg/kg 3x/day for 5 days O NR   20.0 2/20 15.0 3/20 NR   100.0 20/20
3) AZ 0.5 g 3x/day and quinine 10 mg/kg 3x/day for 3 days O NR   19.0 4/21 9.5 2/21 NR   90.5 19/21
4) Doxycycline 100 mg 2x/day and quinine 10 mg/kg 3x/day for 7 days O NR   40.0 4/10 10.0 1/10 NR   100.0 10/10
Pfizer74841§
India
 		 1) AZ 1 g/day and CQ 0.6 g/day for 3 days P/O NR   14.5 12/83 4.8 4/83 2.4 2/83 NR  
2) AZ 0.5 g/day and CQ 0.6 g/day for 3 days P NR   13.4 9/67 6.0 4/67 3.0 2/67 NR  
3) SP 1500 mg/75 mg at start, CQ 0.6 g on day 1 to 2, 0.3 g on day 3 O NR   18.8 15/80 1.3 1/80 0.0 0/80 NR  
Pfizer 82576
Ghana, Kenya, Mali, Uganda, Zambia		 1) AZ 1 g/day and CQ 0.6 g/day for 3 days P 9.6 11/114 18.4 21/114 12.3 14/114 51.8 59/114 16.7 19/114
2) AZ 0.5 g/day and CQ 0.6 g/day for 3 days P 0.0 0/9 22.2 2/9 0.0 0/9 22.2 2/9 0.0 0/9
3) Mefloquine 750 mg at start, 500 mg after 6 hours P 17.4 20/115 25.2 29/115 10.4 12/115 9.6 11/115 33.9 39/115
Pfizer 84227
Colombia/Surinam		 1) AZ 1 g/day and CQ 0.6 g/day for 3 days P NR   6.1 7/114 5.3 6/114 25.4 29/114 NR  
2) AZ 0.5 g/day and CQ 0.6 g/day for 3 days P NR   14.3 2/14 0.0 0/14 28.6 4/14 NR  
3) Atovaquone 1000/proguanil 400 mg/day for 3 days P NR   4.3 5/116 4.3 5/116 2.6 3/116 NR  
Pfizer 84240
Indonesia		 1) AZ 1 g/day and CQ 0.6 g/day for 3 days P 53.8 7/13 30.8 4/13 7.7 1/13 NR   15.4 2/13
2) AZ  0.5 g/day and CQ 0.6 g/day for 3 days P 28.6 2/7 42.9 3/7 14.3 1/7 NR   28.6 2/7
3) SP 1500 mg/75 mg at start, CQ 0.6 g on day 1 to 2, 0.3 g on day 3 P 16.7 2/12 16.7 2/12 16.7 2/12 NR   8.3 1/12
Pfizer 367653
Burkina Faso, Ghana, Kenya, Mali, Senegal, Zambia		 1) AZ 1 g/day and CQ 0.6 g/day for 3 days O 11.5 13/113 4.4 5/113 12.4 14/113 28.3 32/113 19.5 22/113
2) Mefloquine 750 mg at start, 500 mg after 6 to 10 hours O 15.5 18/116 25.0 29/116 5.2 6/116 1.7 2/116 23.3 27/116
Sykes 2009
Tanzania		 1) Azithromycine 20 mg/kg/day and artesunate 4 mg/kg/day for 3 days O NR 7.8 10/129 NR 5.4 7/129 1.6 2/129
2) Artemether 20 mg and lumefantrine 120 mg 2x/day for < 15 kg and 40 mg/240 mg 2x/day for ≥15 kg for 3 days O NR 1.5 2/132 NR 3.0 4/132 0.8 1/132
Thriemer 2010*
Bangladesh		 1) Azithromycin 1.5 g/day and artesunate 200 mg/day for 3 days. Children < 35 kg: azithromycin 30 mg/kg/day, and artesunate 4 mg/kg/day for 3 days. O 7.8 10/128 6.3 8/128 3.9 5/128 NR NR
2) Artemether 80 mg and lumefantrine 480 mg 2x/day for 3 days. Children < 35 kg: artemether 4 mg/kg and lumefantrine 24 mg/kg 2x/day for 3 days O 18.5 12/65 3.1 2/65 0 0/65 NR NR
  Excluded studies                      
Pfizer 282919
India, Colombia		 1) AZ 2 g/day and CQ 0.6 g/day for 3 days O 30.0 33/110 18.2 20/110 11.8 13/110 3.6 4/110 NR