Ericsson 1983.

Methods	Randomised, double‐blind, placebo‐controlled trial Method of randomisation not stated Patients kept daily diary of symptoms and medication doses
Participants	148 US students attending summer school in Guadalajara, Mexico during the summer of 1980 Entry criteria: four or more unformed stools pers 24 hours or three unformed stools per 8 hours; diarrhoea of no more than 48 hours' duration; at least one of: abdominal pain, cramps, nausea, vomiting, fever
Interventions	Treatment: Bicozamycin 500 mg orally 4 times daily for 3 days Comparison: Placebo orally 4 times daily for 3 days
Outcomes	1. Time from initiation of treatment to passage of last unformed stool 2. Number of unformed stools passed per 24 hour interval from initiation of treatment 3. Failed: Moderate to severe illness with more than 6 unformed stools per day and moderate cramps, nausea or vomiting
Notes	97 participants (66%) had positive stool cultures Major pathogenic organisms: ETEC ‐ 49 (33%), Shigella ‐ 25 (17%), Salmonella ‐ 6 (4%), Rotavirus ‐ 5 (3%) Data on pre‐ and post‐treatment antibiotic sensitivities not reported