Karabay 2004.

Methods	Randomized controlled trial Duration: December 1999 and December 2001
Participants	Number: 34 patients enrolled Inclusion criteria: the presence of signs and symptoms compatible with brucellosis including a positive agglutination titre (≥1/160) and/or a positive culture. Exclusion criteria: history of seizure, pregnancy, and age under 15 years.
Interventions	1‐doxycycline 100 mg two times daily and rifampicin 600 mg once daily for 45 days 2‐ofloxacin 400 mg once daily and rifampicin 600 mg once daily for 30 days
Outcomes	1‐clinical relapse 2‐adverse drug reactions 3‐time to defervescence
Notes	Location: the Social Security Duzce Hospitaland Abant Izzet Baysal University, Duzce Medical School, Turkey. Setting: hospitalised patients Source of funding: not mentioned
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding (performance bias and detection bias) All outcomes	High risk	Open study
Incomplete outcome data (attrition bias) All outcomes	High risk	18 patients were randomized to DR, and 16 to OR. Four patients in DR and 1 in OR did not appear in follow‐ups. Four left because they felt well, and one refused to use the drugs. However, the proportion of missing outcomes compared with observed events was considerable.
Selective reporting (reporting bias)	Low risk	Important outcomes are reported
Other bias	Low risk