Rodriguez Zapata 1987.

Methods	Randomized controlled trial Duration: not stated
Participants	Number: 72 patients enrolled. [two patients were excluded from this review due to spondylitis] Inclusion criteria:1)presence of a clinical picture compatible with acute brucellosis.2) Rose Bengal test positive and/or positive blood culture for Brucella. Exclusion criteria: patients with severe concomitant diseases, patients requiring treatments with corticosteroids, barbiturates or other antibiotics, pregnant women, patients younger than 13 or older than 70 years, patients for whom any of the four antibiotics to be used were contraindicated.
Interventions	1‐ doxycycline 200 mg once daily, plus rifampicin 900 mg orally once daily plus for 45 days 2‐ doxycycline 200 mg orally once daily plus streptomycin 1 g intramuscularly, daily for 21 days
Outcomes	1‐relapse 2‐therapeutic failure 3‐adverse drug reactions
Notes	Location: Spain Setting: hospitalised patients (?) Source of funding: not mentioned
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding (performance bias and detection bias) All outcomes	High risk
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	36 patients were randomized to each group. In DR group, 2 patients did not complete the treatment, and 2 were lost to follow‐up.
Selective reporting (reporting bias)	Unclear risk	Time to defervescence was measured, but not reported.
Other bias	Low risk