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. 1998 Jul 27;1998(3):CD000527. doi: 10.1002/14651858.CD000527

Hien VNM 89‐90.

Methods Randomised, method not specified
No exclusion or loss to follow‐up reported
Participants 79 Vietnamese adults
15 to 52 years
Cerebral malaria (clinical signs with unrousable coma, Glasgow scale <10)
Asexual falciparum parasitaemia
Interventions ARTpr + MQ10 vs ASiv + MQ10 vs QNNiv:
 1. ART 2800 mg (600 mg at 0 h and 4 h, 400 mg at 24 h, 32 h, 48 h and 56 h) + MQ 500 mg (single dose, sequential)
 2. AS 240 mg (60 mg at 0 h and 4h, 60 mg at 24 h and 48h) + MQ 500 mg (single dose, sequential)
 3. QNN 500 mg, every 8 hours for 14 days
 
 All patients managed according to WHO 1986 recommendations
Outcomes 1. Mortality
 2. FCT
 3. Time to regain full consciousness (Glasgow scale 15)
 4. PCT (50, 90, 100%)
Notes Quality assessment: B, B, C
ART & AS: supplied by Prof Guo Qiao Li