Hien VNM 89‐90.
Methods | Randomised, method not specified No exclusion or loss to follow‐up reported |
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Participants | 79 Vietnamese adults 15 to 52 years Cerebral malaria (clinical signs with unrousable coma, Glasgow scale <10) Asexual falciparum parasitaemia |
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Interventions | ARTpr + MQ10 vs ASiv + MQ10 vs QNNiv: 1. ART 2800 mg (600 mg at 0 h and 4 h, 400 mg at 24 h, 32 h, 48 h and 56 h) + MQ 500 mg (single dose, sequential) 2. AS 240 mg (60 mg at 0 h and 4h, 60 mg at 24 h and 48h) + MQ 500 mg (single dose, sequential) 3. QNN 500 mg, every 8 hours for 14 days All patients managed according to WHO 1986 recommendations | |
Outcomes | 1. Mortality 2. FCT 3. Time to regain full consciousness (Glasgow scale 15) 4. PCT (50, 90, 100%) | |
Notes | Quality assessment: B, B, C ART & AS: supplied by Prof Guo Qiao Li |