Hien VNM 91.

Methods	Patients allocated at random in pairs, method not specified; open No exclusions or loss to follow‐up reported
Participants	Vietnamese adults 15 to 45 years Severe falciparum malaria (WHO 1986) Falciparum parasitaemia Excluded: pregnancy; parenteral QNN in previous 4h
Interventions	ASim + MQ10 vs ASiv + MQ10 AS 2 mg/kg at 0 h, 1 mg/kg at 12 h and 24 h, then daily until patient able to take oral medication + MQ 500 mg (single dose, sequential) Unconcious patients: single dose phenobarbitone intramuscular Hypoglycaemia: dextrose 1mg/kg intravenous
Outcomes	1. Mortality 2. Incidence of complications 3. FCT 4. PCT 5. Rate of parasite clearance (graph)
Notes	Quality assessment: B, B, A AS from Guilin No2 Pharmaceutical Factory, 60 mg ampoules anhydrous powder reconstituted in 0.6 ml sodium bicarbonate, diluted to 5 ml in 5% dextrose