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. 1998 Jul 27;1998(3):CD000527. doi: 10.1002/14651858.CD000527

Karbwang THI 91.

Methods Randomised, method not specified
No exclusions or loss to follow‐up reported
Participants 26 Thai adults (25 male)
15 to 45 years
Severe falciparum malaria (WHO 1990b).
Excluded: antimalarials in previous 24 h
Interventions AMim vs QNNiv:
 1. AM: 160 mg on day 1, 80 mg on days 2 to 7)
 2. QNN: 20 mg/kg on day 1, 10 mg/kg every 8 h to day 7
Outcomes 1. Mortality by day 7
 2. FCT 
 3. PCT 
 4. Time to recover conciousness 
 5. Neurological sequelae 
 6. Adverse effects
Notes Quality assessment: B, B, C
Arthermin (80 mg ampule)