Date	Event	Description
29 July 2008	Review declared as stable	This review was first published in 1999, Issue 2, and was undertaken to provide a comprehensive assessment of the benefits and risks of this new class of antimalarial drugs in different epidemiological settings. It aimed to inform drug policy decisions on their rational use, and the clinical questions addressed by the review were based on what needed clarifying at that time. The comparison of artemether versus quinine for treating severe malaria was subsequently assessed in a meta‐analysis of individual patient data (Artemether‐Quinine Meta‐analysis Study Group. A meta‐analysis using individual patient data of trials comparing artemether with quinine in the treatment of severe falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2001;95(6):637‐50), which supported the findings of this review of summary data. Further research and development in this area has focused on specific preparations of arteether and artemether. Trials of these preparations, including new trials conducted through the World Health Organization, are now assessed as separate Cochrane Reviews. It is, therefore, no longer necessary or expedient to update this review in its existing format. It will continue to appear in the Cochrane Database of Systematic Reviews for information only.
29 July 2008	Amended	Converted to new review format with minor editing.
24 May 2005	Amended	Minor update.
10 January 2000	New citation required and conclusions have changed	Substantive amendment.
16 December 1999	New search has been performed	New studies found and included or excluded.