White GAM 89.
Methods | Randomised, method not specified, open No exclusions No loss to follow‐up |
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Participants | 43 Gambian children; severe malaria (WHO 1990b) Excluded: antimalarials in previous 4 h |
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Interventions | AM intramuscular vs CLQ intramuscular:
1. AM 4 mg/kg on day 1, 2 mg/kg daily
2. CLQ 3.5 mg/kg every 6 h (per os when able to take fluids by mouth) Temperature > 38.5 °C treated with fanning, sponging and paracetamol; intravenous fluids, ampicillin, benzylpenicillin, gentamicin, diazepam, paraldehyde given as indicated clinically; all comatose patients given intramuscular phenobarbitone; blood transfusion if PCV < 15% |
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Outcomes | 1. Mortality 2. FCT 3. PCT (50, 90, 100%) 4. Time to reach coma score 5; time to drink, sit, stand, walk; 5. Incidence of recurrent seizures, hypoglycaemia, septicaemia, transfusion 6. Adverse effects | |
Notes | Quality assessment: B, B, A Artemether 80 mg/ml Kunming Pharmaceuticals |