White GAM 89.

Methods	Randomised, method not specified, open No exclusions No loss to follow‐up
Participants	43 Gambian children; severe malaria (WHO 1990b) Excluded: antimalarials in previous 4 h
Interventions	AM intramuscular vs CLQ intramuscular: 1. AM 4 mg/kg on day 1, 2 mg/kg daily 2. CLQ 3.5 mg/kg every 6 h (per os when able to take fluids by mouth) Temperature > 38.5 °C treated with fanning, sponging and paracetamol; intravenous fluids, ampicillin, benzylpenicillin, gentamicin, diazepam, paraldehyde given as indicated clinically; all comatose patients given intramuscular phenobarbitone; blood transfusion if PCV < 15%
Outcomes	1. Mortality 2. FCT 3. PCT (50, 90, 100%) 4. Time to reach coma score 5; time to drink, sit, stand, walk; 5. Incidence of recurrent seizures, hypoglycaemia, septicaemia, transfusion 6. Adverse effects
Notes	Quality assessment: B, B, A Artemether 80 mg/ml Kunming Pharmaceuticals