Anh VNM 92‐95.

Methods	Centralised randomisation, allocation concealed in opaque sealed envelopes; open No exclusions or loss to follow‐up reported Follow‐up: 7 to 14 days hospitalisation
Participants	190 Vietnamese adults Cerebral malaria (Choray coma scale 3, equivalent Glasgow 3‐6) with or without other visceral complications Pf parasitaemia
Interventions	ASiv vs QNNiv: 1. AS240: 60 mg at 0 h, 4 h, 24 h and 48h, plus MQ15 oral on day 7 2. QNN: 20 mg/kg over 4 h then 10 mg/kg every 8 h to day 7
Outcomes	1. Mortality 2. Coma recovery time 3. PCT (50, 95 & 100%) 4. FCT
Notes	Quality assessment: A, A, A AS: Guilin No.2 Pharmaceutical Factory, China; supplied by WHO