De Alencar 1997.

Methods	Randomized controlled trial Length of follow up: 28 d Generation of allocation sequence: unclear Allocation concealment: unclear Blinding: none Inclusion of all randomized participants in the final analysis: 154 analysed/175 randomized (88%)
Participants	Number enrolled: 175 Age range: 18 to 65 years Gender: male Inclusion criteria: adult men; age 18 to 68 years; smear positive falciparum malaria; general good health; parasitaemia between 1000 and 100,000 parasites/µL Exclusion criteria: grossly abnormal laboratory results; refusal to be hospitalized for 28 d; inability to tolerate study medication; missing study medication
Interventions	1. Atovaquone plus proguanil (atovaquone 1 g and proguanil 400 mg daily for 3 d) 2. Quinine plus tetracycline (600 mg quinine 3 times a day and 250 mg tetracycline 4 times a day for 7 d)
Outcomes	1. 28‐d cure rate 2. Parasite clearance time 3. Fever clearance time 4. Adverse events
Notes	Location: Brazil Drug resistance: high for chloroquine, sulfadoxine‐pyrimethamine, and quinine to some extent