Looareesuwan 1999a.

Methods	Randomized controlled trial Length of follow up: 28 d Generation of allocation sequence: unclear Allocation concealment: unclear Blinding: none Inclusion of all randomized participants in the final analysis: 158 analysed/182 randomized (87%)
Participants	Number enrolled: 182 Age range: 15 to 63 years Gender: male and female Inclusion criteria: age 16 to 65 years; presence of acute uncomplicated falciparum malaria; parasitaemia between 1000 and 200,000/µL; weight 40 kg and above Exclusion criteria: presence of mixed infections with other Plasmodium species; presence of concomitant disease (intercurrent febrile infections); inability to take oral treatment (persistent vomiting); pregnancy; breastfeeding mother
Interventions	1. Atovaquone plus proguanil (1000 mg atovaquone and 400 mg proguanil daily over 3 d) 2. Mefloquine (1250 mg over 6 h)
Outcomes	1. 28‐d cure rate 2. Parasite clearance time 3. Fever clearance
Notes	Location: Thailand Drug resistance: high for chloroquine and sulfadoxine‐pyrimethamine