Table 5.
Haplotype Association
| Haplotype | Frequency | Case, control frequencies | X2 | P |
|---|---|---|---|---|
| Hispanic Whites: rs28945096 (T/C), rs28945095 (C/T), rs28945094 (T/C), rs12623857 (T/C), rs28945091 (C/A), rs28945090 (G/A), rs28945089 (C/G), rs16863657 (T/C), and rs28945085 (C/G) | ||||
| TCTCCGGTC | 0.52 | 0.46, 0.58 | 1.78 | 0.18 |
| TCTCCGCCC | 0.25 | 0.35, 0.15 | 6.37 | 0.01* |
| TCTCCGCTC | 0.09 | 0.10, 0.10 | 0.00 | 0.98 |
| TCTTCGCTG | 0.03 | 0.02, 0.05 | 1.03 | 0.31 |
| TCTCAGCCC | 0.03 | 0.05, 0.02 | 1.03 | 0.31 |
| TCTTCGCTC | 0.03 | 0.02, 0.05 | 0.86 | 0.35 |
| CCTCCGCTC | 0.02 | 0.02, 0.02 | 0.00 | 1.00 |
| Non-Hispanic whites: rs28945096 (T/C), rs28945094 (T/C), PAX3_C701A, rs28945093 (A/C), rs12623857 (T/C), PAX3_G-569C, rs28945668 (C/T), rs28945088 (C/G), rs28945087 (C/T), rs28945086 (T/C), rs16863657 (T/C), and rs28945085 (C/G) | ||||
| TTCACGCCCTTC | 0.65 | 0.64, 0.66 | 0.10 | 0.76 |
| TTCACGCCCTCC | 0.17 | 0.20, 0.16 | 0.23 | 0.63 |
| TTCATGCCCTTG | 0.06 | 0.06, 0.06 | 0.00 | 0.95 |
| TTCATGCCCTTC | 0.04 | 0.06, 0.20 | 2.16 | 0.14 |
| TCCACGCCCTTC | 0.02 | 0.00, 0.04 | 2.48 | 0.12 |
| African Americans: rs28945092 (C/G), rs12623857 (T/C), PAX3_G-396C, and rs28945035 (C/G) | ||||
| CCGC | 0.71 | 0.67, 0.75 | 0.12 | 0.73 |
| GCGC | 0.07 | 0.00, 0.13 | 0.81 | 0.37 |
| CTGC | 0.07 | 0.00, 0.13 | 0.81 | 0.37 |
| CTCC | 0.07 | 0.17, 0.00 | 1.44 | 0.23 |
| CTGG | 0.07 | 0.17, 0.00 | 1.44 | 0.23 |
| Others: rs28945094 (T/C), rs12623857 (T/C), rs28945089 (C/G), and rs16863657 (T/C) | ||||
| TCGT | 0.59 | 0.70, 0.47 | 1.06 | 0.30 |
| TCCT | 0.21 | 0.10, 0.33 | 1.53 | 0.22 |
| TCCC | 0.10 | 0.10, 0.10 | 0.00 | 1.00 |
| CCGT | 0.05 | 0.10, 0.00 | 1.05 | 0.30 |
| TTGC | 0.03 | 0.00, 0.05 | 0.51 | 0.47 |
| TTCC | 0.03 | 0.00, 0.05 | 0.51 | 0.47 |
*
P < .05.