Regulators of PLZF mRNA expression. A, PLZF copy number and PLZF mRNA expression in TCGA (n = 333). B, Androgen receptor signature and PLZF mRNA expression in HPFS and PHS combined (n = 404). C,
PTEN copy number and PLZF mRNA expression in TCGA (n = 333). D, PTEN by immunohistochemistry and PLZF mRNA expression in HPFS and PHS (n = 260). In panels A–E, horizontal lines indicate the medians; boxes reach from the first to the third quartiles; whiskers extend 1.5 times the interquartile range. E–F, Regulators of PLZF expression in multivariable models in the TCGA primary prostate cancer cohort (E) and in HPFS and PHS combined (F). All units of tumor PLZF expression are standard deviations.