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Downstream consequences of low PLZF in HPFS and PHS. A, PLZF mRNA expression and a signature of MAPK signaling (n = 404). Horizontal lines indicate the medians; boxes reach from the first to the third quartiles; whiskers extend 1.5 times the interquartile range. B, PLZF mRNA expression and risk of lethal disease over long-term follow-up in a multivariable model adjusting for patient, histologic, and genomic covariates.
