Comparison 1.

Treatment versus no treatment

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 No parasitological cure (day 4 to 2 weeks)	6	672	Risk Ratio (M‐H, Fixed, 95% CI)	0.19 [0.15, 0.23]
2 No parasitological cure (6 weeks)	1	429	Risk Ratio (M‐H, Fixed, 95% CI)	0.08 [0.05, 0.13]
3 No parasitological cure (3 months)	2	465	Risk Ratio (M‐H, Fixed, 95% CI)	0.17 [0.13, 0.22]
4 Side effects	4		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 Any side effect	3	524	Risk Ratio (M‐H, Fixed, 95% CI)	1.31 [0.96, 1.78]
4.2 Unpleasant taste	1	443	Risk Ratio (M‐H, Fixed, 95% CI)	3.07 [1.09, 8.66]
4.3 Nausea	3	503	Risk Ratio (M‐H, Fixed, 95% CI)	2.54 [1.14, 5.66]
4.4 Vomiting	3	503	Risk Ratio (M‐H, Fixed, 95% CI)	1.13 [0.45, 2.83]
4.5 Headache	3	503	Risk Ratio (M‐H, Fixed, 95% CI)	0.95 [0.46, 1.93]
4.6 Dizziness	2	472	Risk Ratio (M‐H, Fixed, 95% CI)	0.68 [0.41, 1.12]