Comparison 9.

Metronidazole versus tinidazole

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 No parasitological cure (3‐21 days)	8	595	Risk Ratio (M‐H, Fixed, 95% CI)	3.24 [1.66, 6.32]
2 No parasitological cure (4 weeks)	2	77	Risk Ratio (M‐H, Fixed, 95% CI)	0.58 [0.13, 2.49]
3 No clinical improvement	5	426	Risk Ratio (M‐H, Fixed, 95% CI)	3.81 [1.83, 7.90]
4 Side effects	7		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 Any side effect	6	458	Risk Ratio (M‐H, Fixed, 95% CI)	1.65 [1.35, 2.02]
4.2 Side effect requiring treatment	2	166	Risk Ratio (M‐H, Fixed, 95% CI)	4.56 [0.79, 26.34]
4.3 Bitter taste	2	191	Risk Ratio (M‐H, Fixed, 95% CI)	0.93 [0.57, 1.51]
4.4 Anorexia	2	191	Risk Ratio (M‐H, Fixed, 95% CI)	1.64 [0.84, 3.22]
4.5 Nausea	4	342	Risk Ratio (M‐H, Fixed, 95% CI)	1.50 [1.03, 2.17]
4.6 Vomiting	4	342	Risk Ratio (M‐H, Fixed, 95% CI)	3.40 [1.42, 8.16]
4.7 Ataxia	1	132	Risk Ratio (M‐H, Fixed, 95% CI)	2.43 [0.49, 12.06]
4.8 Dizziness	4	342	Risk Ratio (M‐H, Fixed, 95% CI)	1.27 [0.59, 2.72]
4.9 Abdominal discomfort	1	69	Risk Ratio (M‐H, Fixed, 95% CI)	0.73 [0.13, 4.08]