Tidwell 1994

Methods	Random number table used to prepare consecutively numbered, sealed envelopes containing the medication. Placebos were used. Outcome assessments were blinded.
Participants	Women, 15‐65 years old, seen in the emergency department (Jackson, USA) with a diagnosis of trichomoniasis.
Interventions	Metronidazole 2 g vaginal cream + oral placebo versus metronidazole 2 g oral + vaginal placebo. Partners were offered treatment with a single 2 g dose of metronidazole. Women were asked to abstain from coitus and alcohol until follow up.
Outcomes	Parasitological cure on day 3‐5. Clinical cure. Side effects.
Notes	Both wetmount smear and culture were done but patients were enrolled according to culture results. All patients had cultures for N. gonorrhea, 20% and 14% were positive in the oral and vaginal groups, respectively. Of the 305 patients tested for possible enrolment, 302 could be evaluated. 94 were positive and 61 of these could be enrolled (they needed to be called back). Loss to follow up was 7/61 (11.4%) and one was excluded because of bacterial overgrowth in culture.