Kauffman 1992a.
Methods | Randomized, double blind placebo controlled Follow up: antipyretic effect for 8 hours; adverse events for 24 hours |
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Participants | 37 children aged 2 to 12 years with intercurrent febrile illness, oral temperature at ≥ 38.3 ºC at least one hour before enrollment | |
Interventions | Paracetamol: 10mg/kg Ibuprofen: 7.5 or 10mg/kg; placebo |
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Outcomes | Percentage decrease in temperature from baseline Area under the curve of percentage decrease in temperature against time Treatment failures and adverse events |
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Notes | Study location: USA Treatment failures were treated with 10mg/kg of paracetamol regardless of original treatment group |