Wilson 1991.

Methods	Randomized (method not stated), parallel, modified double‐blind, placebo controlled trial Followed up for 6 to 12 hours
Participants	178 children aged 3 months to 12 years, rectal temperature 38.3 to 40.5 ºC, with clinically stable condition Exclusion criteria: received antipyretic 2 hours before study entry; or antibiotics 12 hours before study entry; history of febrile seizures within 6 months; cancer; hypersensitivity to study or related drugs; severe illness
Interventions	Paracetamol: 12.5mg/kg Ibuprofen: 5 and 10mg/kg Placebo: 0.5ml/kg (single dose)
Outcomes	Rate of temperature fall Time to maximum antipyresis Mean change in temperature over time Area under the curve of antipyresis Adverse events
Notes	Study location: USA No losses to follow up or withdrawals recorded

C: Centigrade; F: Fahrenheit; PCV: packed cell volume; PHA‐IL6: phytohaemagglutinin‐interleukin‐6; PHA‐TNF: phytohaemagglutinin‐tumor necrosis factor.