| Methods | Generation of allocation sequence: table of random numbers. Allocation concealment: unclear. Blinding: not feasible. Length of follow up: 1 hour. |
|
| Participants | 73 children between 6 weeks and 4 years with rectal temperature 102 ° F or higher. Exclusion criteria: antipyretic within 4 hours; antibiotics within past 72 hours; history of febrile convulsion or allergy to acetaminophen. |
|
| Interventions | 1. Acetaminophen alone (n = 26). 2. Tepid sponging alone (n = 19). 3. Acetaminophen plus tepid sponging (n = 28). | |
| Outcomes | Mean temperature at 30 and 60 minutes after initiation of therapy. | |
| Notes | Study location: St. Louis, Missouri, USA. | |
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