Study	Reason for exclusion
Bailey 1974	Not RCT. Non‐randomized comparison of INH versus no INH on hepatotoxicity in hospital employees with LTBI.
Barnwell 1992	RCT: Intervention was additional health education and counselling to improve completion of INH prophylaxis.
Batki 2002	RCT: Interventions were methadone and DOT to improve completion of INH prophylaxis in opioid‐dependent patients with LTBI.
Bridge 1967	Not a clinical trial: view point advocating roll out of INH treatment for LTBI in Michigan.
Byrd 1977	RCT: INH versus placebo comparison of hepatotoxicity.
Catie 2001	Not an original study; a commentary on another RCT of post‐treatment INH versus placebo for prevention of recurrent TB.
Chaisson 2001	RCT: 3 × 2 factorial evaluation of twice‐weekly DOT versus daily self‐administration with peer counselling versus routine care, and monthly $ 10 stipend to improve adherence to INH prophylaxis in injection drug users with LTBI.
Coly 2004	Not RCT: a study of factors associated with completion of LTBI treatment.
Comstock 1967	Cluster RCT: comparison of INH versus placebo.
Comstock 1972	Not RCT; exploratory analysis of an RCT of INH versus placebo (Comstock 1967) and subsequent population roll out of INH for prevention of active TB among people with "untreated non‐active TB".
Comstock 1974	RCT: Follow‐up report on two RCTs of INH versus placebo.
Cowie 1996	RCT: comparison of rifampicin plus INH plus pyrazinamide for 3 months versus placebo for prevention of TB among South African gold miners with silicosis.
Debre 1973	RCT: comparison of INH 5 months versus control in TST converters.
Egsmose 1965	RCT: comparison of INH 12 months versus placebo among household contacts of open cases of pulmonary TB.
Eule 1973	RCT: Treatment of active TB.
Eule 1973a	RCT: Treatment of active TB.
Felten 1989	RCT: comparison of INH versus placebo on the size of TST reaction in LTBI.
Ferebee 1962	RCT: comparison of INH versus placebo among household contacts.
Ferebee 1963	RCT: comparison of INH versus placebo in mental institutions.
Ferebee 1968	RCT: Follow‐up report on several United States Public Health Service sponsored RCTs comparing INH versus placebo.
Fielding 2011	Protocol of a cluster RCT: compared routine INH prophylaxis targeted to those identified as at higher risk of TB (due to HIV infection or silicosis) against a "community‐wide" approach in which INH prophylaxis is offered to all employees of gold mines.
Frigati 2011	Not RCT: A cohort analysis within a placebo‐controlled trial of INH compared with placebo in HIV‐positive children.
Gao 2006	Not RCT: meta‐analysis of INH 6 ‐ 12 months versus rifampicin plus pyrazinamide 2 to 3 months.
Geijo 2007	RCT: comparison of INH 6 months versus INH plus rifampicin 3 months; but, included patients with primary TB and radiographic evidence of inactive TB.
Geiter 1987	RCT: treatment of active pulmonary TB.
Glassroth 1977	RCT: comparison of cancer‐related deaths between INH versus placebo groups of two United States Public Health Service sponsored RCTs.
Graham 1996	Not RCT: cohort study of the effect of INH prophylaxis on risk of TB among injection drug users; 942 of 2960 patients were HIV‐positive .
Gupta 1993	RCT: comparison of no treatment versus INH 3 months versus INH plus rifampicin 1 month versus INH plus rifampicin 3 months versus INH plus rifampicin plus pyrazinamide 1 month; INH was given for 3 months only.
Horwitz 1966	RCT: cluster RCT of INH versus placebo among adults in Greenland.
Horwitz 1974	RCT: Another report on Horwitz 1966.
IUAT 1982	RCT: comparison of INH versus placebo.
Jasmer 2002b	Not RCT: Quasi‐randomized comparison of INH 6 months versus rifampicin plus pyrazinamide 2 months; primary outcomes were adverse effects and treatment completion. Quote from report: "Patients who met study criteria and agreed to participate were allocated in alternate weeks."
John 1994	RCT: comparison of INH 12 months versus placebo in dialysis and renal transplant patients.
Krebs 1977	Not RCT: a review article.
Krebs 1979	RCT: comparison of INH versus placebo for the prevention of active TB among patients with fibrotic pulmonary lesions.
Krebs 1980	RCT: comparison of INH versus placebo; Late results of Krebs 1979.
Lienhardt 2011	RCTin adults with newly diagnosed smear‐positive pulmonary TB.
Madhi 2011	RCT: INH versus placebo in HIV‐ positive children and HIV‐negative children exposed to HIV during the perinatal period.
Martinson 2011	RCT: participants were adults with HIV infection.
Moulton 2007	Not RCT: describes the design of a randomized evaluation of health services intervention to implement routine testing for LTBI and treatment with INH among HIV‐ positive patients in Brazil.
Mount 1962	RCT: comparison of INH versus placebo for the prevention of TB among household contacts.
Nazareth 1971	RCT: comparison of post‐treatment INH versus placebo for the prevention of recurrent TB; two RCTs.
Nunn 2011	RCT: Participants were people with newly diagnosed smear positive TB.
Samandari 2011	RCT: participants were adults with HIV infection.
Schechter 2006	RCT: comparison of weekly INH plus rifapentine 12 weeks versus daily rifampicin plus pyrazinamide 8 weeks among household contacts of PTB.
Spyridis 2007	NOt RCT: Quasi‐randomized; two independent comparisons of INH 9 months versus INH plus rifampicin 4 months and INH plus rifampicin 4 months versus INH plus rifampicin 3 months. Outcomes were treatment completion, adverse events, and active TB. Quote from report: "Patients were randomly assigned to 1 of 2 groups on the basis of their number in the clinic (odd or even)."
Veening 1968	RCT: comparison of INH versus placebo.

RCT: Randomized Controlled Trial

INH: Isoniazid