2. Risk of bias of included trials^a.

Trial	Generation of allocation sequence	Allocation concealment	Blinding	Inclusion of all randomized participants in the final analysisb
Bounyasong 2001	Unclear	Unclear	None	Adequate
Coulibaly 2006	Adequate	Unclear	None	Inadequate
Kalilani 2007	Adequate	Adequate	Outcome assessor	Inadequate
Mbanzulu 1993	Inadequate	Unclear	Outcome assessor	Adequate
McGready 2000	Adequate	Unclear	None	Adequate
McGready 2001a	Unclear	Unclear	None	Inadequate
McGready 2005	Adequate	Adequate	Outcome assessor	Adequate
Nosten 1993b	Inadequate	Unclear	None	Inadequate
Sowunmi 1998a	Unclear	Unclear	None	Adequate
Tagbor 2006	Adequate	Adequate	Participant, treatment provider, outcome assessor, data analyst	Adequate

^aSee 'Assessment of risk of bias in included studies' for the assessment methods, and the 'Characteristics of included studies' for the methods used in each trial.
 ^bFor primary outcomes.