| Outcome |
Trial |
Artesunate |
Quinine |
Comparative results reported in article |
| Coma recovery time (h): median (range), number |
Hien 1992 |
35 (5 to 453); mode = 17; mean = 68.9 |
48 (7 to 144), mode = 43; mean = 58.1 |
'Not significantly different'. |
| Cao 1997 |
42 (4 to 228), n = 10 |
31 (4 to 66), n = 2 |
‐ |
| Newton 2003 |
17 (1 to 125), n = 16 |
18 (1 to 188), n = 16 |
'P = 0.6' |
| Eltahir 2010 |
mean = 8.1 (SD not given), n = 4 |
mean = 9.1, (SD not given), n = 5 |
'P=0.4' |
| Time to localise pain (h): median (IQR), number |
Dondorp 2010 |
12 (6 to 24), n = 698 |
12 (6 to 24), n = 726 |
'Hazard Ratio 0·87 (0·78–0·98), P = 0.0093' |
| Time to speak (h/days): median (IQR), number |
Dondorp 2005 |
1 day (0.2 to 0.35), n = 730 |
1 day (0.2 to 0.21), n = 731 |
'P = 0.73' |
| Dondorp 2010 |
20 hrs (8 to 42), n = 664 |
18 hrs (11 to 36), n = 695 |
'Hazard Ratio 0·88 (0·79–0·99), P = 0.016' |
| Time to hospital discharge (d): median (range/IQR), number |
Cao 1997 |
8 (5 to 20), n = 33 |
8 (5 to 24), n = 29 |
'P = 0.99' |
| Dondorp 2005 |
5 (0 to 54), n = 623 |
5 (0 to 45), n = 567 |
'P = 0.20' |
| Dondorp 2010 |
3 (IQR 2 to 5), n = 2478 |
3 (IQR 2 to 5) n = 2412 |
'P = 0.059' |
| Fever clearance time (until first below 37.5 °C) (h): median (range), number |
Cao 1997 |
4 (4 to 198), n = 35 |
8 (0 to 96), n = 35 |
'P = 0.17' |
| Newton 2003 |
11 (1 to 83), n = 42 |
13 (1 to 184), n = 42 |
'P = 0.2' |
| Fever clearance time (until remains below 37.5 °C for 24 h) (h): median (range), number |
Cao 1997 |
84 (4 to 198), n = 35 |
81 (0 to 246), n = 30 |
'P = 0.62' |
| Newton 2003 |
41 (3 to 138), n = 32 |
65 (12 to 383), n = 27 |
'P = 0.2' |
| Time to parasite clearance of 50% (h): median (range), number |
Cao 1997 |
5.7 (2.0 to 15.3), n = 35 |
13.2 (2.4 to 103.0), n = 32 |
'P < 0.0001' |
| Newton 2003 |
9.1 (0.3 to 37.2), n = 56 |
8.0 (0.2 to 46.0), n = 49 |
'P = 0.3' |
| Time to parasite clearance of 90% (h): median (range), number |
Cao 1997 |
12.0 (3.7 to 35.0), n=35 |
27.7 (7.5 to 107.0), n=32 |
'P < 0.0001' |
| Newton 2003 |
20.5 (2.8 to 50.11), n=54 |
24.7 (0.9 to 67.7), n=48 |
'P = 0.08' |
| Time to parasite clearance of 100% (h): median (range), number |
Cao 1997 |
36.0 (16.0 to126.0), n=34 |
84.0 (12.0 to 240.0), n=32 |
'P < 0.0001' |
